MEDIE is based on indexing by Natural Language Processing and Text Mining techniques. The text mining tools focus on certain biological entities like proteins (iHOP) (Hoffman and Valencia, 2005) and certain grammatical structures like subject-verb-object. MEDIE provides an interface to create semantic queries. This "Semantic Search", which consists of up to three terms entered in the fields for subject, verb, and/or object, retrieves documents based on the semantic similarity of the query to sentences in MEDLINE articles, which have all been parsed and grammatically analyzed by the system beforehand. MEDIE then presents sentences containing the query terms in the given context (i.e., used as subject/verb/object), plus links the extracted sentences to the MEDLINE abstracts.