KNIME integrates various components for machine learning and data mining through its modular data pipelining concept. A graphical user interface and use of JDBC allows assembly of nodes blending different data sources, including preprocessing (ETL: Extraction, Transformation, Loading), for modeling, data analysis and visualization without, or with only minimal, programming. Since 2006, KNIME has been used in pharmaceutical research,[3] it also used in other areas like CRM customer data analysis, business intelligence, and financial data analysis. KNIME's headquarters are based in Zurich, with additional offices in Konstanz, Berlin, and Austin.